Targeting the fibroblast growth factor receptor family in cancer
نویسندگان
چکیده
منابع مشابه
Targeting fibroblast growth factor receptor signaling inhibits prostate cancer progression.
PURPOSE Extensive correlative studies in human prostate cancer as well as studies in vitro and in mouse models indicate that fibroblast growth factor receptor (FGFR) signaling plays an important role in prostate cancer progression. In this study, we used a probe compound for an FGFR inhibitor, which potently inhibits FGFR-1-3 and significantly inhibits FGFR-4. The purpose of this study is to de...
متن کاملThe fibroblast growth factor family.
Acidic and basic fibroblast growth factors are structurally related monomeric proteins which have been purified from a diverse set of vertebrate tissues. These prototype FGFs2 are mitogenic toward a broad spectrum of mesodermand ectoderm-derived cells and can also serve as trophic factors and as mediators of developmental pathways in a variety of in vitro and in vivo systems. Within the past 3 ...
متن کاملTargeting fibroblast growth factor pathways in prostate cancer.
Advanced prostate cancer carries a poor prognosis and novel therapies are needed. Research has focused on identifying mechanisms that promote angiogenesis and cellular proliferation during prostate cancer progression from the primary tumor to bone-the principal site of prostate cancer metastases. One candidate pathway is the fibroblast growth factor (FGF) axis. Aberrant expression of FGF ligand...
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Chemotherapy has become the global standard treatment for patients with metastatic or unresectable gastric cancer (GC), although outcomes remain unfavorable. Many molecular-targeted therapies inhibiting signaling pathways of various tyrosine kinase receptors have been developed, and monoclonal antibodies targeting human epidermal growth factor receptor 2 (HER2) have become standard therapy for ...
متن کاملCancer Therapy: Preclinical Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression
Purpose: Extensive correlative studies in human prostate cancer as well as studies in vitro and in mouse models indicate that fibroblast growth factor receptor (FGFR) signaling plays an important role in prostate cancer progression. In this study, we used a probe compound for an FGFR inhibitor, which potently inhibits FGFR-1–3 and significantly inhibits FGFR-4. The purpose of this study is to d...
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ژورنال
عنوان ژورنال: Cancer Treatment Reviews
سال: 2016
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2016.03.015